The main purpose of this study was to prepare a novel in situ gelling system for oral sustained delivery of Famotidine and study the effect of concentration of gellan gum on various physiochemical characteristics of formulation and also study the effect on drug release from the gel. An ion-activated in situ gel was developed and characterized with gellan gum (0.2%-1%) as a carrier. The formulation contained calcium ions in complexed form, the release of which in the acidic environment of the stomach caused gelation of the gellan gum. As the concentration of gellan gum was increased from 0.2% to 1% the in-vitro release of drug decreased but strength of gel increased. In vitro release characteristics were determined at a receptor solution of pH 1.2 using USP dissolution test apparatus with a paddle stirrer at 50 rpm. In vitro studies demonstrated controlled release of famotidine from the gels for upto 8 hours. Other properties like insitu gelation time, viscosity was also studied. In situ-gelling gellan formulations was successfully developed and It was concluded that prolonged gastro residence time resulting from the in situ gel of famotidine might contribute to better receptor blocking action.
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